Blar i forfatter "Urbanics, Rudolf"

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    • Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes 

      Wibroe, Peter Popp; Anselmo, Aaron C; Nilsson, Per; Sarode, Apoorva; Gupta, Vivek; Urbanics, Rudolf; Szebeni, Janos; Hunter, Alan Christy; Mitragotri, Samir; Mollnes, Tom Eirik; Moghimi, Seyed Moein (Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-04-10)
      Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying mechanisms are poorly understood, roles for both the complement system and reactive macrophages have been implicated. Here, we show the dominance and importance of robust ...

    • A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood 

      Pethő, Ákos; Piecha, Dorothea; Mészáros, Tamás; Urbanics, Rudolf; Moore, Christoph; Canaud, Bernard; Mollnes, Tom Eirik; Steppan, Sonja; Szénási, Gábor; Szebeni, János; Dézsi, László (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-09)
      Hemodialysis reactions (HDRs) resemble complement-activation-related pseudoallergy (CARPA) to certain i.v. drugs, for which pigs provide a sensitive model. On this basis, to better understand the mechanism of human HDRs, we subjected pigs to hemodialysis using polysulfone (FX CorDiax 40, Fresenius) or cellulose triacetate (SureFlux-15UX, Nipro) dialyzers, or Dialysis exchange-set without membranes, ...

    • Pseudo-anaphylaxis to polyethylene glycol (PEG)-coated liposomes: Roles of anti-PEG IgM and complement activation in a porcine model of human infusion reactions 

      Kozma, Gergely Tibor; Mészáros, Támas; Vashegyi, Ildikó; Fülöp, Tamás Gábor; Örfi, Erik; Dézsi, László; Rosivall, László; Bavli, Yaelle; Urbanics, Rudolf; Mollnes, Tom Eirik; Barenholz, Yechezkel; Szebeni, János (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-26)
      Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier to the use of these drugs, yet its mechanism is poorly understood. This study showed that a single i.v. injection in pigs of a low dose of PEGylated liposomes (Doxebo) induced ...